is a specific kind of: negative stimulus.

is a broader term that covers: nuisance | irritant, thorn | plague.

derivation: annoy, bother, chafe, devil, get at, get to, gravel, irritate, nark, nettle, rag, rile, vex | bother | anguish, hurt, pain | bother, discommode, disoblige, incommode, inconvenience, put out, trouble.