A state of depression and anhedonia so severe as to require clinical intervention.

synonyms: depression, depressive disorder.

Roget 503: disordered reason, disordered intellect; diseased mind, unsound mind, abnormal mind; derangement, unsoundness; psychosis; neurosis; cognitive disorder; affective disorder^†.    insanity, lunacy; madness etc. adj.; mania, rabies, furor, mental alienation, aberration; paranoia, schizophrenia; dementation^†, dementia, demency^†; phrenitis^†, phrensy^†, frenzy, raving, incoherence, wandering, delirium, calenture of the brain^†; delusion, hallucination; lycanthropy^†; brain storm^†.    vertigo, dizziness, swimming; sunstroke, coup de soleil [Fr.], siriasis^†.    fanaticism, infatuation, craze; oddity, eccentricity, twist, monomania (caprice) 608; kleptodipsomania^†; hypochondriasis [Med.] etc. (low spirits) 837; melancholia, depression, clinical depression, severe depression; hysteria; amentia^†.    screw loose, tile loose, slate loose; bee in one's bonnet, rats in the upper story.    dotage etc. (imbecility) 499.    ... show more